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==NMR structure of the ubiquitin-binding zinc finger (UBZ) domain from human Rad18==
==NMR structure of the ubiquitin-binding zinc finger (UBZ) domain from human Rad18==
<StructureSection load='2mrf' size='340' side='right'caption='[[2mrf]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mrf' size='340' side='right'caption='[[2mrf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MRF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MRF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAD18, RNF73 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mrf OCA], [https://pdbe.org/2mrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mrf RCSB], [https://www.ebi.ac.uk/pdbsum/2mrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mrf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mrf OCA], [https://pdbe.org/2mrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mrf RCSB], [https://www.ebi.ac.uk/pdbsum/2mrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mrf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RAD18_HUMAN RAD18_HUMAN]] E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.<ref>PMID:17108083</ref> <ref>PMID:21659603</ref>
[https://www.uniprot.org/uniprot/RAD18_HUMAN RAD18_HUMAN] E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.<ref>PMID:17108083</ref> <ref>PMID:21659603</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bezsonova, I]]
[[Category: Bezsonova I]]
[[Category: Korzhnev, D M]]
[[Category: Korzhnev DM]]
[[Category: Rizzo, A A]]
[[Category: Rizzo AA]]
[[Category: Salerno, P E]]
[[Category: Salerno PE]]
[[Category: Dna repair]]
[[Category: Ligase]]
[[Category: Translesion synthesis]]
Retrieved from "https://proteopedia.org/2mrf"