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==HADDOCK calculated model of LIN5001 bound to the HET-s amyloid==
==HADDOCK calculated model of LIN5001 bound to the HET-s amyloid==
<StructureSection load='2mus' size='340' side='right'caption='[[2mus]], [[NMR_Ensembles_of_Models | 4 NMR models]]' scene=''>
<StructureSection load='2mus' size='340' side='right'caption='[[2mus]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mus]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Podas Podas]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mus]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3LS:3,4-BIS(CARBOXYMETHYL)-2,2 5,2 5,2 5,2-QUINQUETHIOPHENE-5,5-DICARBOXYLIC+ACID'>3LS</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3LS:3,4-BIS(CARBOXYMETHYL)-2,2 5,2 5,2 5,2-QUINQUETHIOPHENE-5,5-DICARBOXYLIC+ACID'>3LS</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lbu|2lbu]], [[2rnm|2rnm]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">het-s, small s ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5145 PODAS])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mus OCA], [https://pdbe.org/2mus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mus RCSB], [https://www.ebi.ac.uk/pdbsum/2mus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mus ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mus OCA], [https://pdbe.org/2mus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mus RCSB], [https://www.ebi.ac.uk/pdbsum/2mus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mus ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HETS_PODAS HETS_PODAS]] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.<ref>PMID:1886611</ref> <ref>PMID:8224826</ref> <ref>PMID:9275200</ref>
[https://www.uniprot.org/uniprot/HETS_PODAS HETS_PODAS] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.<ref>PMID:1886611</ref> <ref>PMID:8224826</ref> <ref>PMID:9275200</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Podas]]
[[Category: Podospora anserina]]
[[Category: Aguzzi, A]]
[[Category: Aguzzi A]]
[[Category: Aslund, A K.O]]
[[Category: Aslund AKO]]
[[Category: Ballmer, B]]
[[Category: Ballmer B]]
[[Category: Bockmann, A]]
[[Category: Bockmann A]]
[[Category: Budka, H]]
[[Category: Budka H]]
[[Category: Caflisch, A]]
[[Category: Caflisch A]]
[[Category: Hammarstrom, P]]
[[Category: Hammarstrom P]]
[[Category: Hermann, U S]]
[[Category: Hermann US]]
[[Category: Hornemann, S]]
[[Category: Hornemann S]]
[[Category: Huang, D H]]
[[Category: Huang DH]]
[[Category: Li, B]]
[[Category: Li B]]
[[Category: Mason, J J]]
[[Category: Mason JJ]]
[[Category: Meier, B H]]
[[Category: Meier BH]]
[[Category: Nilsson, P K.R]]
[[Category: Nilsson PKR]]
[[Category: Nuvolone, M]]
[[Category: Nuvolone M]]
[[Category: Rushing, E]]
[[Category: Rushing E]]
[[Category: Saban, D]]
[[Category: Saban D]]
[[Category: Schuetz, A K]]
[[Category: Schuetz AK]]
[[Category: Shirani, H]]
[[Category: Shirani H]]
[[Category: Amyloid fibril]]
[[Category: Beta-solenoid]]
[[Category: Luminescent conjugated polythiophene]]
[[Category: Parallel beta-sheet]]
[[Category: Prion]]
[[Category: Protein fibril]]
Retrieved from "https://proteopedia.org/2mus"