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==Structure of the E. coli Threonylcarbamoyl-AMP Synthase TSAC==
==Structure of the E. coli Threonylcarbamoyl-AMP Synthase TSAC==
<StructureSection load='2mx1' size='340' side='right'caption='[[2mx1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mx1' size='340' side='right'caption='[[2mx1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MX1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MX1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b3282, JW3243, rimN, tsaC, yrdC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mx1 OCA], [https://pdbe.org/2mx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mx1 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-threonylcarbamoyladenylate_synthase L-threonylcarbamoyladenylate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.87 2.7.7.87] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mx1 OCA], [https://pdbe.org/2mx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mx1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TSAC_ECOLI TSAC_ECOLI]] Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.[HAMAP-Rule:MF_01852]<ref>PMID:15716138</ref> <ref>PMID:19287007</ref> <ref>PMID:21285948</ref> <ref>PMID:22378793</ref> <ref>PMID:23072323</ref>
[https://www.uniprot.org/uniprot/TSAC_ECOLI TSAC_ECOLI] Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.[HAMAP-Rule:MF_01852]<ref>PMID:15716138</ref> <ref>PMID:19287007</ref> <ref>PMID:21285948</ref> <ref>PMID:22378793</ref> <ref>PMID:23072323</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: L-threonylcarbamoyladenylate synthase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Agris, P F]]
[[Category: Agris PF]]
[[Category: Bilbille, Y]]
[[Category: Bilbille Y]]
[[Category: Bobay, B G]]
[[Category: Bobay BG]]
[[Category: Deutsch, C]]
[[Category: Deutsch C]]
[[Category: Harris, K A]]
[[Category: Harris KA]]
[[Category: Iwata-Reuyl, D]]
[[Category: Iwata-Reuyl D]]
[[Category: Sarachan, K L]]
[[Category: Sarachan KL]]
[[Category: Sims, A F]]
[[Category: Sims AF]]
[[Category: Transferase]]
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