4rrn: Difference between revisions

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<StructureSection load='4rrn' size='340' side='right'caption='[[4rrn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4rrn' size='340' side='right'caption='[[4rrn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rrn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rrn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RRN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UW:(4S,4AS,10AR)-2-AMINO-8-(2-FLUOROPYRIDIN-3-YL)-1-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[IMIDAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-5(1H)-ONE'>3UW</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UW:(4S,4AS,10AR)-2-AMINO-8-(2-FLUOROPYRIDIN-3-YL)-1-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[IMIDAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-5(1H)-ONE'>3UW</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5n|4r5n]], [[4rro|4rro]], [[4rrs|4rrs]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrn OCA], [https://pdbe.org/4rrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rrn RCSB], [https://www.ebi.ac.uk/pdbsum/4rrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrn ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrn OCA], [http://pdbe.org/4rrn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrn RCSB], [http://www.ebi.ac.uk/pdbsum/4rrn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Memapsin 2]]
[[Category: Brown KD]]
[[Category: Brown, K D]]
[[Category: Burkard M]]
[[Category: Burkard, M]]
[[Category: Cox AA]]
[[Category: Cox, A A]]
[[Category: DeLisle RK]]
[[Category: DeLisle, R K]]
[[Category: Dutcher D]]
[[Category: Do, M K.Geck]]
[[Category: Geck Do MK]]
[[Category: Dutcher, D]]
[[Category: Groneberg R]]
[[Category: Groneberg, R]]
[[Category: Hunt KW]]
[[Category: Hunt, K W]]
[[Category: Liao J]]
[[Category: Liao, J]]
[[Category: Liu X]]
[[Category: Liu, X]]
[[Category: Lyssikatos JP]]
[[Category: Lyssikatos, J P]]
[[Category: Newhouse B]]
[[Category: Newhouse, B]]
[[Category: Otten JN]]
[[Category: Otten, J N]]
[[Category: Purkey HE]]
[[Category: Purkey, H E]]
[[Category: Rana S]]
[[Category: Rana, S]]
[[Category: Regal K]]
[[Category: Regal, K]]
[[Category: Rhodes SP]]
[[Category: Rhodes, S P]]
[[Category: Scearce-Levie K]]
[[Category: Scearce-Levie, K]]
[[Category: Siu M]]
[[Category: Siu, M]]
[[Category: Smith D]]
[[Category: Smith, D]]
[[Category: Thomas AA]]
[[Category: Thomas, A A]]
[[Category: Vigers GPA]]
[[Category: Vigers, G P.A]]
[[Category: Watts RJ]]
[[Category: Watts, R J]]
[[Category: Wright AD]]
[[Category: Wright, A D]]
[[Category: Aspartyl protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/4rrn"