7txt: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl== | |||
<StructureSection load='7txt' size='340' side='right'caption='[[7txt]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7txt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TXT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KWC:1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine'>KWC</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7txt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7txt OCA], [https://pdbe.org/7txt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7txt RCSB], [https://www.ebi.ac.uk/pdbsum/7txt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7txt ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Basbaum AI]] | |||
[[Category: Bekele B]] | |||
[[Category: Billesboelle CB]] | |||
[[Category: Boytsov D]] | |||
[[Category: Braz J]] | |||
[[Category: Craik V]] | |||
[[Category: Huang XP]] | |||
[[Category: Lak P]] | |||
[[Category: Manglik A]] | |||
[[Category: O'Donnell H]] | |||
[[Category: Rodriguiz RM]] | |||
[[Category: Roth BL]] | |||
[[Category: Roy K]] | |||
[[Category: Rudnick G]] | |||
[[Category: Sandtner W]] | |||
[[Category: Seth A]] | |||
[[Category: Shoichet BK]] | |||
[[Category: Singh I]] | |||
[[Category: Wetsel WC]] | |||
Revision as of 09:47, 15 March 2023
Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl
| ||||||||||||
