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==Transmembrane domain of mouse Fas/CD95 death receptor==
==Transmembrane domain of mouse Fas/CD95 death receptor==
<StructureSection load='2na6' size='340' side='right'caption='[[2na6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2na6' size='340' side='right'caption='[[2na6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2na6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NA6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2na6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NA6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2na7|2na7]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2na6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na6 OCA], [https://pdbe.org/2na6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2na6 RCSB], [https://www.ebi.ac.uk/pdbsum/2na6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2na6 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fas, Apt1, Tnfrsf6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2na6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na6 OCA], [https://pdbe.org/2na6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2na6 RCSB], [https://www.ebi.ac.uk/pdbsum/2na6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2na6 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.  
[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE] Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).  
[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Chou, J J]]
[[Category: Chou JJ]]
[[Category: Fu, Q]]
[[Category: Fu Q]]
[[Category: Fu, T]]
[[Category: Fu T]]
[[Category: MPSbyNMR, Membrane Protein Structures by Solution NMR]]
[[Category: Wu H]]
[[Category: Wu, H]]
[[Category: Apoptosis]]
[[Category: Membrane protein structures by solution nmr]]
[[Category: Mpsbynmr]]
[[Category: Proline-based motif]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Transmembrane domain]]
[[Category: Transmembrane helix trimer]]
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