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==Transmembrane Structure of the P441A Mutant of the Cytokine Receptor Common Subunit beta==
==Transmembrane Structure of the P441A Mutant of the Cytokine Receptor Common Subunit beta==
<StructureSection load='2na9' size='340' side='right'caption='[[2na9]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
<StructureSection load='2na9' size='340' side='right'caption='[[2na9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2na9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NA9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2na9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NA9 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2na8|2na8]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2na9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na9 OCA], [https://pdbe.org/2na9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2na9 RCSB], [https://www.ebi.ac.uk/pdbsum/2na9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2na9 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSF2RB, IL3RB, IL5RB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2na9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na9 OCA], [https://pdbe.org/2na9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2na9 RCSB], [https://www.ebi.ac.uk/pdbsum/2na9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2na9 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[https://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref>
[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[https://omim.org/entry/614370 614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.  
[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: An, W]]
[[Category: An W]]
[[Category: Ginsberg, M H]]
[[Category: Ginsberg MH]]
[[Category: Schmidt, T]]
[[Category: Schmidt T]]
[[Category: Situ, A J]]
[[Category: Situ AJ]]
[[Category: Ulmer, T S]]
[[Category: Ulmer TS]]
[[Category: Ye, F]]
[[Category: Ye F]]
[[Category: Nbp residue]]
[[Category: Signaling protein]]
[[Category: Transmembrane helix]]
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