2nar: Difference between revisions
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==Solution structure of AVR3a_60-147 from Phytophthora infestans== | ==Solution structure of AVR3a_60-147 from Phytophthora infestans== | ||
<StructureSection load='2nar' size='340' side='right'caption='[[2nar | <StructureSection load='2nar' size='340' side='right'caption='[[2nar]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2nar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2nar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytophthora_infestans Phytophthora infestans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NAR FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nar OCA], [https://pdbe.org/2nar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nar RCSB], [https://www.ebi.ac.uk/pdbsum/2nar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nar ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nar OCA], [https://pdbe.org/2nar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nar RCSB], [https://www.ebi.ac.uk/pdbsum/2nar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nar ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A3AKI_PHYIN A3AKI_PHYIN] Multifunctional effector that can suppress host BAK1/SERK3-mediated immunity through at least two different pathways (PubMed:19794118, PubMed:20457921, PubMed:21348873, PubMed:26348328). Manipulates plant immunity by targeting and stabilizing host E3 ligase CMPG1. Preventing the normal 26S proteasome-dependent degradation of potato CMPG1, and thus potentially of its protein substrates in the host cell, further abolishes host cell death during the biotrophic phase of infection (PubMed:19794118, PubMed:20457921, PubMed:21348873). Associates also with the dynamin-related protein 2 (DRP2), a plant GTPase involved in immune receptor-mediated endocytosis (PubMed:26348328). The Avr3A(KI) form is recognized by R3a which triggers R3a-mediated hypersensitivity and suppresses INF1-induced cell death (PubMed:15894622, PubMed:16965554, PubMed:19245321).<ref>PMID:15894622</ref> <ref>PMID:16965554</ref> <ref>PMID:19245321</ref> <ref>PMID:19794118</ref> <ref>PMID:20457921</ref> <ref>PMID:21348873</ref> <ref>PMID:26348328</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bayer | [[Category: Phytophthora infestans]] | ||
[[Category: Kozminski | [[Category: Bayer P]] | ||
[[Category: Matena | [[Category: Kozminski W]] | ||
[[Category: Stanek | [[Category: Matena A]] | ||
[[Category: Wawra | [[Category: Stanek J]] | ||
[[Category: Wawra S]] | |||
[[Category: Zhukov | [[Category: Zhukov I]] | ||
[[Category: | [[Category: Van West P]] | ||
