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==Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel==
==Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel==
<StructureSection load='2ndj' size='340' side='right'caption='[[2ndj]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2ndj' size='340' side='right'caption='[[2ndj]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ndj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ndj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDJ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNE3, MiRP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndj OCA], [https://pdbe.org/2ndj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndj RCSB], [https://www.ebi.ac.uk/pdbsum/2ndj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndj OCA], [https://pdbe.org/2ndj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndj RCSB], [https://www.ebi.ac.uk/pdbsum/2ndj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndj ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/KCNE3_HUMAN KCNE3_HUMAN]] Brugada syndrome;Hypokalemic periodic paralysis.
[https://www.uniprot.org/uniprot/KCNE3_HUMAN KCNE3_HUMAN] Brugada syndrome;Hypokalemic periodic paralysis.  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KCNE3_HUMAN KCNE3_HUMAN]] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.[UniProtKB:Q9JJV7]<ref>PMID:10646604</ref> <ref>PMID:12954870</ref>
[https://www.uniprot.org/uniprot/KCNE3_HUMAN KCNE3_HUMAN] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.[UniProtKB:Q9JJV7]<ref>PMID:10646604</ref> <ref>PMID:12954870</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: George, A L]]
[[Category: George AL]]
[[Category: Horn, W D.Van]]
[[Category: Kang C]]
[[Category: Kang, C]]
[[Category: Kroncke BM]]
[[Category: Kroncke, B M]]
[[Category: Meiler J]]
[[Category: Meiler, J]]
[[Category: Nannemann DP]]
[[Category: Nannemann, D P]]
[[Category: Sanders CR]]
[[Category: Sanders, C R]]
[[Category: Sisco NJ]]
[[Category: Sisco, N J]]
[[Category: Smith J]]
[[Category: Smith, J]]
[[Category: Song Y]]
[[Category: Song, Y]]
[[Category: Van Horn WD]]
[[Category: Vanoye, C G]]
[[Category: Vanoye CG]]
[[Category: Welch, R C]]
[[Category: Welch RC]]
[[Category: Estrogen]]
[[Category: Ion channel]]
[[Category: Membrane protein]]
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