4tlv: Difference between revisions

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==CARDS TOXIN, NICKED==
==CARDS TOXIN, NICKED==
<StructureSection load='4tlv' size='340' side='right' caption='[[4tlv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4tlv' size='340' side='right'caption='[[4tlv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4tlv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycpn Mycpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TLV FirstGlance]. <br>
<table><tr><td colspan='2'>[[4tlv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae_M129 Mycoplasma pneumoniae M129]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TLV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tlw|4tlw]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tlv OCA], [https://pdbe.org/4tlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tlv RCSB], [https://www.ebi.ac.uk/pdbsum/4tlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tlv ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPN_372, MP464 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272634 MYCPN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tlv OCA], [http://pdbe.org/4tlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tlv RCSB], [http://www.ebi.ac.uk/pdbsum/4tlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tlv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CARDS_MYCPN CARDS_MYCPN]] Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of respiratory epithelial integrity in tracheal epithelium and vacuolization in the cytoplasm of CHO and HeLa cells.<ref>PMID:16617115</ref>
[https://www.uniprot.org/uniprot/CARDS_MYCPN CARDS_MYCPN] Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of respiratory epithelial integrity in tracheal epithelium and vacuolization in the cytoplasm of CHO and HeLa cells.<ref>PMID:16617115</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycpn]]
[[Category: Large Structures]]
[[Category: Hart, P J]]
[[Category: Mycoplasma pneumoniae M129]]
[[Category: Pakhomova, O N]]
[[Category: Hart PJ]]
[[Category: Taylor, A B]]
[[Category: Pakhomova ON]]
[[Category: Adp-ribosyl transferase]]
[[Category: Taylor AB]]
[[Category: Atypical pneumonia]]
[[Category: Community acquired respiratory distress syndrome]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Toxin]]
[[Category: Transferase]]
[[Category: Virulence]]