4tmf: Difference between revisions
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==Crystal structure of human CD38 in complex with hydrolysed compound JMS713== | ==Crystal structure of human CD38 in complex with hydrolysed compound JMS713== | ||
<StructureSection load='4tmf' size='340' side='right' caption='[[4tmf]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='4tmf' size='340' side='right'caption='[[4tmf]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4tmf]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4tmf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TMF FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JS2:5-O-[(R)-{[(S)-[4-(8-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)BUTOXY](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]-ALPHA-D-RIBOFURANOSE'>JS2</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JS2:5-O-[(R)-{[(S)-[4-(8-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)BUTOXY](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]-ALPHA-D-RIBOFURANOSE'>JS2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmf OCA], [https://pdbe.org/4tmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tmf RCSB], [https://www.ebi.ac.uk/pdbsum/4tmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tmf ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Hao | [[Category: Large Structures]] | ||
[[Category: Potter | [[Category: Hao Q]] | ||
[[Category: Swarbrick | [[Category: Potter B]] | ||
[[Category: Zhang | [[Category: Swarbrick J]] | ||
[[Category: Zhang H]] | |||