1k83: Difference between revisions

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[[Image:1k83.gif|left|200px]]
[[Image:1k83.gif|left|200px]]


{{Structure
<!--
|PDB= 1k83 |SIZE=350|CAPTION= <scene name='initialview01'>1k83</scene>, resolution 2.80&Aring;
The line below this paragraph, containing "STRUCTURE_1k83", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=ILX:4,5-DIHYDROXYISOLEUCINE'>ILX</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRX:6-HYDROXYTRYPTOPHAN'>TRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1k83| PDB=1k83  | SCENE= }}  
|RELATEDENTRY=[[1i50|1I50]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k83 OCA], [http://www.ebi.ac.uk/pdbsum/1k83 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k83 RCSB]</span>
}}


'''Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin'''
'''Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin'''
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[[Category: Cramer, P.]]
[[Category: Cramer, P.]]
[[Category: Kornberg, R D.]]
[[Category: Kornberg, R D.]]
[[Category: alpha amanitin]]
[[Category: Alpha amanitin]]
[[Category: molecular machine]]
[[Category: Molecular machine]]
[[Category: mrna]]
[[Category: Mrna]]
[[Category: multiprotein complex]]
[[Category: Multiprotein complex]]
[[Category: transcription]]
[[Category: Transcription]]
[[Category: zinc motif]]
[[Category: Zinc motif]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:25:09 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:41 2008''

Revision as of 19:25, 2 May 2008

File:1k83.gif

Template:STRUCTURE 1k83

Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin


Overview

The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.

About this Structure

1K83 is a Protein complex structure of sequences from Amanita phalloides and Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1K83 with [RNA Polymerase]. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:11805306 Page seeded by OCA on Fri May 2 22:25:09 2008

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