4tse: Difference between revisions

<table><tr><td colspan='2'>[[4tse]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TSE FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tse OCA], [https://pdbe.org/4tse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tse RCSB], [https://www.ebi.ac.uk/pdbsum/4tse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tse ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN] Left ventricular noncompaction. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.<ref>PMID:24121310</ref>  

*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Blacklow SC]]

[[Category: McMillan BJ]]