Sandbox Reserved 1768: Difference between revisions
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=== Significant Residues === | === Significant Residues === | ||
The vast majority of residues involved in bile salt uptake are also involved in HBV/HDV infection. <scene name='95/952696/Residues_84-87_1/1'>Residues 84-87</scene> (extracellular view) of Human NTCP have been shown to be vital for preS1 domain recognition along with bile salt uptake. <scene name='95/952696/Residues_157-165/1'>Residues 157-165</scene> (extracellular view) have also been shown to be vital for preS1 recognition and bile salt uptake. Altering residues in either of these two | The vast majority of residues involved in bile salt uptake are also involved in HBV/HDV infection. <scene name='95/952696/Residues_84-87_1/1'>Residues 84-87</scene> (extracellular view) of Human NTCP have been shown to be vital for preS1 domain recognition along with bile salt uptake. <scene name='95/952696/Residues_157-165/1'>Residues 157-165</scene> (extracellular view) have also been shown to be vital for preS1 recognition and bile salt uptake. Altering residues in either of these <scene name='95/952696/Residues_84-87_and_157-165/1'>two extracellular patches</scene> hinders preS1 binding and therefore HBV/HDV infection. However, these mutations also prevent bile salt uptake. | ||
== Molecular Mechanism == | == Molecular Mechanism == | ||
