7u4v: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 7u4v is ON HOLD until Paper Publication~~

==CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE==

~~Authors: Khan, J.A.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[7u4v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4V FirstGlance]. <br>

~~Description:~~ CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZN:6-[(cyclopropanecarbonyl)amino]-4-{[(4M)-3-methoxy-4-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl]amino}-N-methylpyridazine-3-carboxamide'>LZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4v OCA], [https://pdbe.org/7u4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4v RCSB], [https://www.ebi.ac.uk/pdbsum/7u4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4v ProSAT]</span></td></tr>

[[Category: Khan~~, J.A~~]]

</table>

== Disease ==

[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

== Function ==

[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Khan JA]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7u4v is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE==
+<StructureSection load='7u4v' size='340' side='right'caption='[[7u4v]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
-Authors: Khan, J.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7u4v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4V FirstGlance]. <br>
-Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZN:6-[(cyclopropanecarbonyl)amino]-4-{[(4M)-3-methoxy-4-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl]amino}-N-methylpyridazine-3-carboxamide'>LZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4v OCA], [https://pdbe.org/7u4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4v RCSB], [https://www.ebi.ac.uk/pdbsum/7u4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4v ProSAT]</span></td></tr>
-[[Category: Khan, J.A]]
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
+== Function ==
+[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Khan JA]]