8ce9: Difference between revisions
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==Crystal structure of human Cd11b I domain in C121 space group== | |||
<StructureSection load='8ce9' size='340' side='right'caption='[[8ce9]], [[Resolution|resolution]] 2.11Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ce9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CE9 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ce9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ce9 OCA], [https://pdbe.org/8ce9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ce9 RCSB], [https://www.ebi.ac.uk/pdbsum/8ce9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ce9 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. | ||
[[Category: | __TOC__ | ||
[[Category: Ni | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Coker J]] | ||
[[Category: | [[Category: Gao Q]] | ||
[[Category: Koekemoer L]] | |||
[[Category: MacLean EM]] | |||
[[Category: Marsden B]] | |||
[[Category: Midwood K]] | |||
[[Category: Ni X]] | |||
[[Category: Schwenzer A]] | |||
[[Category: Von Delft F]] | |||
[[Category: Williams E]] | |||
[[Category: Wright ND]] | |||
Revision as of 07:22, 22 March 2023
Crystal structure of human Cd11b I domain in C121 space group
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