Sandbox Reserved 1774: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
== Introduction == | == Introduction == | ||
In humans, the hypothalamic-pituitary-thyroid (HPT) signaling axis regulates functions including metabolism, growth, organ development, and neural differentiation <ref name="Brent">Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122(9):3035-3043. | In humans, the hypothalamic-pituitary-thyroid (HPT) signaling axis regulates functions including metabolism, growth, organ development, and neural differentiation <ref name="Brent">Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122(9):3035-3043. [https://doi.org/10.1172/JCI60047 DOI: 10.1172/JCI60047]</ref>. In this pathway, the thyroid stimulating hormone receptor (TSHR) activates transcription of thyroid hormones in response to ligand binding by thyroid stimulating hormone (TSH). After a brief introduction to the biological significance of TSHR, this page explores the structure of TSHR and its significance to TSH binding and receptor activation. | ||
== Biological Significance of TSHR == | == Biological Significance of TSHR == | ||
