Sandbox Reserved 1769: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 43: | Line 43: | ||
=== Mechanism of Bile Salt Uptake === | === Mechanism of Bile Salt Uptake === | ||
Bile salts recognize and bind to the <scene name='95/952697/Ntcp_open-pore_state_surface/1'>open-pore state</scene>. After binding, bile salts pass through the amphipathic pore ( | Bile salts recognize and bind to the <scene name='95/952697/Ntcp_open-pore_state_surface/1'>open-pore state</scene>. After binding, bile salts pass through the amphipathic pore (shown below) [[Image:Hydrophobicity pore.jpg|450 px|right|thumb|Hydrophobicity Scale PyMol picture of NTCP. Red represents hydrophobic residues and white represents hydrophilic residues.]] and NTCP transitions into the <scene name='95/952697/Ntcp_inward_facing_state/1'>inward facing state</scene>. In this conformation, the pore closes off relative to the extracellular side and opens to the cytoplasmic side. Transition to the inward facing state allows release of bile salts and sodium ions. It is not yet known how this transition exactly proceeds. | ||
=== Mechanism of HBV/HDV Infection === | === Mechanism of HBV/HDV Infection === | ||
