Sandbox Reserved 1769: Difference between revisions
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=== Mechanism of Bile Salt Uptake === | === Mechanism of Bile Salt Uptake === | ||
Bile salts recognize and bind to the <scene name='95/952697/Ntcp_open-pore_state_surface/1'>open-pore state</scene>. After binding, bile salts pass through the amphipathic pore (shown below) [[Image:Hydrophobicity pore.jpg|450 px|right|thumb|Hydrophobicity Scale PyMol picture of NTCP. Red represents hydrophobic residues and white represents hydrophilic residues.]] and NTCP transitions into the <scene name='95/952697/Ntcp_inward_facing_state/1'>inward facing state</scene>. In this conformation, the pore closes off relative to the extracellular side and opens to the cytoplasmic side. Transition to the inward facing state allows release of bile salts and sodium ions. It is not yet known how this transition exactly proceeds. | Bile salts recognize and bind to the <scene name='95/952697/Ntcp_open-pore_state_surface/1'>open-pore state</scene>. After binding, bile salts pass through the amphipathic pore (shown below) [[Image:Hydrophobicity pore.jpg|450 px|right|thumb|Hydrophobicity Scale PyMol picture of NTCP. Red represents hydrophobic residues and white represents hydrophilic residues.]] and NTCP transitions into the <scene name='95/952697/Ntcp_inward_facing_state/1'>inward facing state</scene>. In this conformation, the pore closes off relative to the extracellular side and opens to the cytoplasmic side. Transition to the inward facing state allows release of bile salts and sodium ions. It is not yet known how this transition exactly proceeds. | ||
[[Image:Bile_Salt_Mechanism.png|450 px|right|thumb|Mechanism of Bile Salt Uptake by NTCP.]] | |||
=== Mechanism of HBV/HDV Infection === | === Mechanism of HBV/HDV Infection === | ||
