Sandbox Reserved 1783: Difference between revisions

The conformational change of NTCP's core domain helices are essential to bile salt binding and uptake. Figure 1 displays the topology of NTCP, highlighting both the panel (shown in blue) and core (shown in purple and pink) domains. Helices 3 and 8 are the main structural components of the conformational change. Before bile salt can bind, the pore in which salt binds must be <scene name='95/952711/Open_pore_ntcp_non_transparent/1'>open</scene>. The open pore is flipped open toward the outer membrane to allow for binding. Once <scene name='95/952711/Open_pore_with_bile_salts/1'>bound</scene>, the pore is <scene name='95/952711/Closed_pore_ntcp/1'>closed</scene>, and bile salt is able to be released into the cell, past the inner membrane.