Sandbox Reserved 1778: Difference between revisions
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=== SHOC2 === | === SHOC2 === | ||
leucine rich repeat | SHOC2 is a domain which acts as a cradle to bind PP1C and MRAS. The | ||
<scene name='95/952706/ | <scene name='95/952706/Shoc2_structure/1'>Structure of SHOC2</scene> | ||
is a leucine rich repeat (LRR) protein that consists of 20 consecutive LRR domains. It is stabilized by an asparagine ladder and this motif results in an extended beta sheet on the inner concavity of the protein surface with alpha helices facing outward. This results in a largely hydrophobic core. | |||
=== MRAS === | |||
<scene name='95/952706/Mras_structure/1'>MRAS</scene> | |||
binds to SHOC2 primarily by the descending loop and strands of each LRR domains 2-10. Once associated with SHOC2, it binds to PP1C and guides the holoenzyme complex to the cell membrane to begin signaling. | |||
=== PP1C === | === PP1C === | ||
protein phosphatase 1 catalytic subunit | protein phosphatase 1 catalytic subunit (PP1C) is highly characterized of serine/ threonine phosphatase. | ||
<scene name='95/952706/Pp1c_structure/1'>PP1C | <scene name='95/952706/Pp1c_structure/1'>PP1C</scene> | ||
associates with the ascending loops of the SHOC2 LRR regions. | |||
= Interactions = | = Interactions = | ||
