4unx: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 3: Line 3:
<StructureSection load='4unx' size='340' side='right'caption='[[4unx]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4unx' size='340' side='right'caption='[[4unx]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4unx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/eq/newmarket/93/(h3n8)) Influenza a virus (a/eq/newmarket/93/(h3n8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UNX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4unx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/eq/Newmarket/93/(H3N8)) Influenza A virus (A/eq/Newmarket/93/(H3N8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UNX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4unw|4unw]], [[4uny|4uny]], [[4unz|4unz]], [[4uo0|4uo0]], [[4uo1|4uo1]], [[4uo2|4uo2]], [[4uo3|4uo3]], [[4uo4|4uo4]], [[4uo5|4uo5]], [[4uo6|4uo6]], [[4uo7|4uo7]], [[4uo8|4uo8]], [[4uo9|4uo9]], [[4uoa|4uoa]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4unx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unx OCA], [https://pdbe.org/4unx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4unx RCSB], [https://www.ebi.ac.uk/pdbsum/4unx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4unx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4unx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unx OCA], [http://pdbe.org/4unx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4unx RCSB], [http://www.ebi.ac.uk/pdbsum/4unx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4unx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q82847_9INFA Q82847_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]  
[https://www.uniprot.org/uniprot/Q82847_9INFA Q82847_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 20:


==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 27: Line 26:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Collins, P J]]
[[Category: Collins PJ]]
[[Category: Gamblin, S J]]
[[Category: Gamblin SJ]]
[[Category: Haire, L F]]
[[Category: Haire LF]]
[[Category: Martin, S R]]
[[Category: Martin SR]]
[[Category: Ogrodowicz, R W]]
[[Category: Ogrodowicz RW]]
[[Category: Skehel, J J]]
[[Category: Skehel JJ]]
[[Category: Vachieri, S G]]
[[Category: Vachieri SG]]
[[Category: Walker, P A]]
[[Category: Walker PA]]
[[Category: Xiong, X]]
[[Category: Xiong X]]
[[Category: Canine]]
[[Category: Equine]]
[[Category: Haemagglutinin]]
[[Category: Influenza]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/4unx"