4uou: Difference between revisions
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<StructureSection load='4uou' size='340' side='right'caption='[[4uou]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='4uou' size='340' side='right'caption='[[4uou]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4uou]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4uou]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UOU FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand= | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uou OCA], [https://pdbe.org/4uou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uou RCSB], [https://www.ebi.ac.uk/pdbsum/4uou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uou ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/LECF_ASPFU LECF_ASPFU] Multispecific lectin that is able to recognize L-fucose in all possible linkages (PubMed:23695231, PubMed:27058347, PubMed:24340081, PubMed:25760594). These could be found not only in decomposed plant matter in soil, which is the natural environment for A.fumigatus, but also in various epitopes on human tissues (PubMed:25760594). Mediates binding of A.fumigatus conidia to airway mucinin a fucose dependent manner (PubMed:27058347). Stimulates IL-8 production by human bronchial cells in a dose-dependent manner, contributing to the inflammatory response observed upon the exposure of a patient to A.fumigatus, and thus might be an important virulence factor involved in an early stage of A.fumigatus infection (PubMed:24340081).<ref>PMID:23695231</ref> <ref>PMID:24340081</ref> <ref>PMID:25760594</ref> <ref>PMID:27058347</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Aspergillus fumigatus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cioci | [[Category: Cioci G]] | ||
[[Category: Houser | [[Category: Houser J]] | ||
[[Category: Imberty | [[Category: Imberty A]] | ||
[[Category: Komarek | [[Category: Komarek J]] | ||
[[Category: Varrot | [[Category: Varrot A]] | ||
[[Category: Wimmerova | [[Category: Wimmerova M]] | ||
