4v0p: Difference between revisions
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<StructureSection load='4v0p' size='340' side='right'caption='[[4v0p]], [[Resolution|resolution]] 2.07Å' scene=''> | <StructureSection load='4v0p' size='340' side='right'caption='[[4v0p]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v0p]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4v0p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V0P FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0p OCA], [https://pdbe.org/4v0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v0p RCSB], [https://www.ebi.ac.uk/pdbsum/4v0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v0p ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MAGA3_HUMAN MAGA3_HUMAN] Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.<ref>PMID:20864041</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aitkenhead | [[Category: Aitkenhead H]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Cooper | [[Category: Cooper CDO]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Gileadi O]] | ||
[[Category: Gileadi | [[Category: Newman JA]] | ||
[[Category: Newman | [[Category: Pinkas DM]] | ||
[[Category: Pinkas | [[Category: Von Delft F]] | ||
[[Category: | |||