Sandbox Reserved 1773: Difference between revisions
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===Medical Relevancy=== | ===Medical Relevancy=== | ||
Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. | Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. | ||
===Disease=== | |||
B-cells and their respective receptors play an important role in the immune response. Therefore, if the receptors were to not function properly, there would be damaging consequences. [https://en.wikipedia.org/wiki/Autoimmune_disease Autoimmune disease] is suggested to occur when somatic cells are recognized as foreign antigens and the body tries to eliminate them. It is thought that B-cell receptors are an essential part of these diseases due to their function and role in the immune systems. B-cell receptors are improperly recognizing somatic cells from different tissues depending on the disease and eliciting a response against them. Examples of these diseases include [https://en.wikipedia.org/wiki/Rheumatoid_arthritis rheumatoid arthritis] where the lining of joints is targeted and degraded, [https://en.wikipedia.org/wiki/Multiple_sclerosis multiple sclerosis] which targets the myelin sheath that surrounds nerve cells, [https://en.wikipedia.org/wiki/Type_1_diabetes type 1 diabetes mellitus] where the insulin producing cells are targeted for destruction, and [https://en.wikipedia.org/wiki/Lupus systematic lupus erythematosus] where multiple organ systems are targeted (skin, brain, lungs, and kidneys are common targets). | |||
===Therapeutics=== | |||
