Sandbox Reserved 1769: Difference between revisions

<scene name='95/952697/Ntcp_open-pore_state/25'>Glycine and proline residues</scene> in the connecting loops and extra- and intracellular helices (Figure 3) act as hinges in the mechanism of bile salt uptake. This flexibility allows separation of the core and panel domains, creating a pore open to the extracellular space and exposing critical Na+ binding sites. Once substrate binds the open-pore state, this hinge allows the transition to close this pore relative to the extracellular side and open to the cytoplasmic side, thus allowing release of substrate into the cell.<ref name = "Goutam" />