Sandbox Reserved 1780: Difference between revisions
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Thyroid-stimulating hormone (TSH) (GREEN LINK) is a hormone that stimulates the thyroid gland to produce proteins that are vital for many metabolic pathways in the body's tissue. TSH activates the TSHR protein by binding to the concave surface of the LRRD and hinge region to keep TSHR in its active state by clashing with the membrane <ref name="Duan"> DOI:10.1038/s41586-022-05173-3</ref>. (Figure 2). This clash is caused by glycosylations of an asparagine 52 residue on the alpha subunit of TSH (GREEN LINK). These modifications to the ASN residue are N-acetyl glucosamine modifications (Figure 3). They stick out from the alpha subunit of TSH to clash with the cell membrane and keep TSH in the active state. | Thyroid-stimulating hormone (TSH) (GREEN LINK) is a hormone that stimulates the thyroid gland to produce proteins that are vital for many metabolic pathways in the body's tissue. TSH activates the TSHR protein by binding to the concave surface of the LRRD and hinge region to keep TSHR in its active state by clashing with the membrane <ref name="Duan"> DOI:10.1038/s41586-022-05173-3</ref>. (Figure 2). This clash is caused by glycosylations of an asparagine 52 residue on the alpha subunit of TSH (GREEN LINK). These modifications to the ASN residue are N-acetyl glucosamine modifications (Figure 3). They stick out from the alpha subunit of TSH to clash with the cell membrane and keep TSH in the active state. | ||
<scene name='95/952708/M22/3'>M22</scene> | |||
===ML109=== | ===ML109=== | ||
