Sandbox Reserved 1778

This Sandbox is Reserved from February 27 through August 31, 2023 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1765 through Sandbox Reserved 1795.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

Your Heading Here (maybe something like 'Structure')

spinqualitylabelsall models SMP Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Function hydrogen bonding PP1C binds PVxF motif == Disease == == Relevance == == Structure == === SHOC2 === SHOC2 is a domain which acts as a cradle to bind PP1C and MRAS. The <scene name='95/952706/Shoc2_structure/7'>structure of SHOC2 is a leucine rich repeat (LRR) protein that consists of 20 consecutive LRR regions . This motif results in an extended beta sheet on the inner concavity of the protein surface with alpha helices facing outward. This results in a largely hydrophobic core. protein phosphatase 1 catalytic subunit ( PP1C ) is highly characterized of serine/ threonine phosphatase. PP1C associates> associates with the ascending loops of the SHOC2 LRR regions. MRAS MRAS binds to SHOC2 primarily by the descending loop and strands of each LRR domains 2-10. Once associated with SHOC2, it binds to PP1C and guides the holoenzyme complex to the cell membrane to begin signaling. Interactions SHOC2 and PP1C interaction SHOC2 and MRAS interactions MRAS and PP1C interactions This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.