Sandbox Reserved 1777: Difference between revisions
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==SHOC2== | ==SHOC2== | ||
SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS, allowing for the holoenzyme to be functional. The <scene name='95/952705/Shoc2_structure/1'>structure of SHOC2</scene> is a leucine rich repeat (LRR) protein that consists of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR regions</scene>. This motif results in an extended beta sheet on the inner concavity of the protein surface with alpha helices facing outward. This results in a largely hydrophobic core. | SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS, allowing for the holoenzyme to be functional. The <scene name='95/952705/Shoc2_structure/1'>structure of SHOC2</scene> is a leucine rich repeat (LRR) protein that consists of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR regions</scene>. This motif results in an extended beta sheet on the inner concavity of the protein surface with alpha helices facing outward. This results in a largely hydrophobic core<Ref name= 'Hahn'> Kwon, J. J., & Hahn, W. C. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and cellular biology, 41(4), e00627-20 (2021). doi:10.1128/MCB.00627-20. [http://doi.org/10.1128/MCB.00627-20. DOI: 10.1128/MCB.00627-20]. </Ref>. | ||
==PP1C== | ==PP1C== | ||
<scene name='95/952705/Pp1c_structure/1'>PP1C</scene> is a catalytic domain of a phosphatase enzyme [https:// | <scene name='95/952705/Pp1c_structure/1'>PP1C</scene> is a catalytic domain of a phosphatase enzyme [https://www.ncbi.nlm.nih.gov/gene/5499. PP1], which cleaves a phosphate. This subunit is a serine/threonine phosphatase known to be involved in a variety of cellular signaling pathways that control cell growth, division, and metabolism (again cite, see texts). | ||
==MRAS== | ==MRAS== | ||
