Sandbox Reserved 1777: Difference between revisions
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==SHOC2== | ==SHOC2== | ||
[[Image:SHOC2-PP1C-MRAS Surface.JPG|300px|right|thumb|<font size=" | [[Image:SHOC2-PP1C-MRAS Surface.JPG|300px|right|thumb|<font size="2"><div style="text-align: center;">'''Figure 2'''. Surface representation of SHOC2-PP1C-MRAS from PDB 7pui. Blue is SHOC2, orange is PP1C and green is MRAS. </div></font>]] | ||
SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS, allowing for the holoenzyme to be functional. The <scene name='95/952705/Shoc2_structure/1'>structure of SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein that consists of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR regions</scene>. This motif results in an extended beta sheet on the inner concavity of the protein surface with alpha helices facing outward. This results in a largely hydrophobic core<Ref name= 'Hahn'> Kwon, J. J., & Hahn, W. C. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and cellular biology, 41(4), e00627-20 (2021). doi:10.1128/MCB.00627-20. [http://doi.org/10.1128/MCB.00627-20. DOI: 10.1128/MCB.00627-20]. </Ref>. | SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS, allowing for the holoenzyme to be functional. The <scene name='95/952705/Shoc2_structure/1'>structure of SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein that consists of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR regions</scene>. This motif results in an extended beta sheet on the inner concavity of the protein surface with alpha helices facing outward. This results in a largely hydrophobic core<Ref name= 'Hahn'> Kwon, J. J., & Hahn, W. C. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and cellular biology, 41(4), e00627-20 (2021). doi:10.1128/MCB.00627-20. [http://doi.org/10.1128/MCB.00627-20. DOI: 10.1128/MCB.00627-20]. </Ref>. | ||
