Sandbox Reserved 1785: Difference between revisions

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===Significance and Background===

Immunoglobulin M, or IgM, is one of multiple types of immunoglobulins that exist in humans. IgM presents itself on the surface of a B cell to act as a B Cell Receptor (BCR). Upon the binding of an antigen to the BCR, the B cell will activate, proliferate, and produce other Ig compounds. These include IgG, IgD, IgA, and IgE [https://proteopedia.org/wiki/index.php/Antibody antibodies], which all have specific roles in the various forms of immune response. Because of this, activation of the IgM BCR is a critical step in the beginning of an immune response.

The structure of IgM was determined using [https://www.thermofisher.com/us/en/home/electron-microscopy/life-sciences/protein-analysis.html Cryo-EM] to visualize the atoms within the protein. However, due to poor resolution within specific regions of the IgM BCR, not every atom has been able to be visualized.

===History and Discovery===

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===Fc Region===

The constant region of IgM is made up of the 2 <scene name='95/952715/Heavy_chain/1'>heavy chains</scene>. These heavy chains form a bridge to connect the Fab fragment, or variable region, to the transmembrane region. They also act as a wire to allow the variable region to send a cellular signal through to the intermembrane region once an antigen has been bound.

<scene name='95/952715/Alpha_beta_heavy/2'>Alpha, Beta, and Heavy chain interactions</scene> help to stabilize and hold the heavy chains and Ig Alpha/Beta chains together in the extracellular portion of the intermembrane region.

===Fab Region===

Sandbox Reserved 1785: Difference between revisions

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@@ Line 7: / Line 7: @@
 ===Significance and Background===
+Immunoglobulin M, or IgM, is one of multiple types of immunoglobulins that exist in humans. IgM presents itself on the surface of a B cell to act as a B Cell Receptor (BCR). Upon the binding of an antigen to the BCR, the B cell will activate, proliferate, and produce other Ig compounds. These include IgG, IgD, IgA, and IgE [https://proteopedia.org/wiki/index.php/Antibody antibodies], which all have specific roles in the various forms of immune response. Because of this, activation of the IgM BCR is a critical step in the beginning of an immune response.
+The structure of IgM was determined using [https://www.thermofisher.com/us/en/home/electron-microscopy/life-sciences/protein-analysis.html Cryo-EM] to visualize the atoms within the protein. However, due to poor resolution within specific regions of the IgM BCR, not every atom has been able to be visualized.
 ===History and Discovery===
@@ Line 23: / Line 26: @@
 ===Fc Region===
+The constant region of IgM is made up of the 2 <scene name='95/952715/Heavy_chain/1'>heavy chains</scene>. These heavy chains form a bridge to connect the Fab fragment, or variable region, to the transmembrane region. They also act as a wire to allow the variable region to send a cellular signal through to the intermembrane region once an antigen has been bound.
+<scene name='95/952715/Alpha_beta_heavy/2'>Alpha, Beta, and Heavy chain interactions</scene> help to stabilize and hold the heavy chains and Ig Alpha/Beta chains together in the extracellular portion of the intermembrane region.
 ===Fab Region===