Sandbox Reserved 1792: Difference between revisions
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== Active vs Inactive State== | == Active vs Inactive State== | ||
[[Image:Image-Inactive Inactive Proteopedia.png|300 px|right|thumb| An overview of the Inactive (red) vs Active (green) state of TSHR. PDB: 7WX5]] | [[Image:Image-Inactive Inactive Proteopedia.png|300 px|right|thumb| An overview of the Inactive (red) vs Active (green) state of TSHR. PDB: 7WX5]] | ||
When TSHR is not bound to TSH, it is in the inactive state. This is also considered the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashing between TSH and the cell-membrane cause TSHR to take on the active or "up" state. During this transition, the Extracellular domains rotate 55° along an axis. This rotation is caused by conformational changes within the <scene name='95/952720/Hinge_region_spin/1'>Hinge Region</scene>, specifically at the Y279 residue. This residue moves 6 angstroms relative to I486, which is a residue located in the Transmembrane Region <ref name="Faust"/> | When TSHR is not bound to TSH, it is in the <scene name='95/952720/Inactivetshr/1'>inactive state</scene>. This is also considered the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashing between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/5'>active or "up" state</scene>. During this transition, the Extracellular domains rotate 55° along an axis. This rotation is caused by conformational changes within the <scene name='95/952720/Hinge_region_spin/1'>Hinge Region</scene>, specifically at the Y279 residue. This residue moves 6 angstroms relative to I486, which is a residue located in the Transmembrane Region <ref name="Faust"/> | ||
== Specific Residues == | == Specific Residues == | ||
