Sandbox Reserved 598: Difference between revisions
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[[Image:MyJak2.jpg|thumb|250px|left|Not, "just another kinase". Picture from Protein Data Bank.]] | [[Image:MyJak2.jpg|thumb|250px|left|Not, "just another kinase". Picture from Protein Data Bank.]] | ||
Janus Kinase 2 is a non-receptor janus kinase, a protein which is part of the tyrosine kinases. These group of kinases are the primary intracellular mediators of cytokine signaling and are involved in the control of cellular growth. As a non-receptor kinase, Jak 2 has a cytoplasmic enzyme which catalyzes the transfer of a phosphate group through phosphorylation to the tyrosine residue in the protein. Such an enzyme plays a crucial role in regulating various cellular functions by switching on or off additional enzymes within the cell. <ref> Hanks, SK., Quinn, AM., Hunter, T. (1988). The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241 (4861): 42–52. doi:10.1126/science.3291115. PMID 3291115. </ref> Such phosphorylation is a reversible process, and used in many different pathways as a method to control cellular activity. However kinases like Jak2, have enzymes which add phosphate groups to hydroxyl side chains as can be seen in the diagram. <ref> Hudel, H. [Internet]. Irvine [CA]. Center for Biomembrane Systems at UC Irvine; c2013. [Updated 2013 Jan 3; cited 2013 March 23]. Available from: http://bass.bio.uci.edu </ref> | Janus Kinase 2 is a non-receptor janus kinase, a protein which is part of the tyrosine kinases. These group of kinases are the primary intracellular mediators of cytokine signaling and are involved in the control of cellular growth. As a non-receptor kinase, Jak 2 has a cytoplasmic enzyme which catalyzes the transfer of a phosphate group through phosphorylation to the tyrosine residue in the protein. Such an enzyme plays a crucial role in regulating various cellular functions by switching on or off additional enzymes within the cell. <ref> Hanks, SK., Quinn, AM., Hunter, T. (1988). The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241 (4861): 42–52. doi:10.1126/science.3291115. PMID 3291115. </ref> Such phosphorylation is a reversible process, and used in many different pathways as a method to control cellular activity. However kinases like Jak2, have enzymes which add phosphate groups to hydroxyl side chains as can be seen in the diagram. <ref> Hudel, H. [Internet]. Irvine [CA]. Center for Biomembrane Systems at UC Irvine; c2013. [Updated 2013 Jan 3; cited 2013 March 23]. Available from: http://bass.bio.uci.edu </ref> | ||
Jak2 was given its name "Janus" after the two-faced Roman God "Janus" who was known as the custodian of the universe and the God of new beginnings. <ref> Janus incarnate [Internet]. Kirwan Studios; c2011. [Updated 2011 Feb 3; cited 2013 March 23' Retrieved from http://rense.com/general92/janus.htm http://rense.com/general92/janus.htm </ref> The abbreviation 'Jak' is commonly referred to as 'just another kinase' as, when it was first discovered, the kinase's role was not yet fully understood. <ref> Weinberg, I. (April 2010). Janus Kinase (Jak2)”. Vascular Medicind; Angiolgist http://www.angiologist.com/general-medicine/janus-kinase-2-jak2/ </ref> | Jak2 was given its name "Janus" after the two-faced Roman God "Janus" who was known as the custodian of the universe and the God of new beginnings. <ref> Janus incarnate [Internet]. Kirwan Studios; c2011. [Updated 2011 Feb 3; cited 2013 March 23' Retrieved from http://rense.com/general92/janus.htm http://rense.com/general92/janus.htm </ref> The abbreviation 'Jak' is commonly referred to as 'just another kinase' as, when it was first discovered, the kinase's role was not yet fully understood. <ref> Weinberg, I. (April 2010). Janus Kinase (Jak2)”. Vascular Medicind; Angiolgist http://www.angiologist.com/general-medicine/janus-kinase-2-jak2/ </ref> | ||
