Sandbox Reserved 1785: Difference between revisions
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The diagram in figure 2 depicts the initial process of B cell activation by the antigen binding to the antibody at the Fab region. The underlying mechanism for signal transduction is unknown but it is speculated to operate under what is known as the conserved assembly mechanism. This means that upon antigen binding, BCRs on the surface of the cell begin to cluster to cause the phosphorylation of the immunoreceptor tyrosine-based activation motifs located in Igα and Igβ. In its “off” state, the constant region 4 of heavy chain B overlaps the extracellular components of Igα and Igβ. As the antigen binds, it induces a conformational change to release the overlap and allow for clustering about the BCR. Now, in its “on” state the phosphorylation of the ITAM region (observed here as the conserved tyrosine residues are phosphorylated) within the intracellular tails of Igα and Igβ drives downstream kinase activity to continue to process of signal cascading. | The diagram in figure 2 depicts the initial process of B cell activation by the antigen binding to the antibody at the Fab region. The underlying mechanism for signal transduction is unknown but it is speculated to operate under what is known as the conserved assembly mechanism. This means that upon antigen binding, BCRs on the surface of the cell begin to cluster to cause the phosphorylation of the immunoreceptor tyrosine-based activation motifs located in Igα and Igβ. In its “off” state, the constant region 4 of heavy chain B overlaps the extracellular components of Igα and Igβ. As the antigen binds, it induces a conformational change to release the overlap and allow for clustering about the BCR. Now, in its “on” state the phosphorylation of the ITAM region (observed here as the conserved tyrosine residues are phosphorylated) within the intracellular tails of Igα and Igβ drives downstream kinase activity to continue to process of signal cascading. | ||
[[Image: | [[Image:Signal_binding.png|400 px|left|thumb|'''Figure 2. IgM Antibody Signal Transduction following Antigen Binding.''']] | ||
</StructureSection> | </StructureSection> | ||
