7ssa: Difference between revisions
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==Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome== | |||
<StructureSection load='7ssa' size='340' side='right'caption='[[7ssa]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ssa]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SSA FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ssa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ssa OCA], [https://pdbe.org/7ssa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ssa RCSB], [https://www.ebi.ac.uk/pdbsum/7ssa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ssa ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CBF1_YEAST CBF1_YEAST] Required for chromosome stability and methionine prototrophy. It is involved in chromosomal segregation. Binds to a highly conserved DNA sequence (5'-RTCACRTG-3'), called CDEI, found in centromeres and in several promoters. DNA-binding activity is enhanced by MET28. Required as an auxiliary factor for transcriptional activation of sulfur metabolism together with MET4 and MET28.<ref>PMID:1549123</ref> <ref>PMID:8665859</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Eek P]] | |||
[[Category: Tan S]] | |||
Revision as of 06:21, 7 April 2023
Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome
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