2qt4: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2qt4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scytonema_varium Scytonema varium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QT4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2qt4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scytonema_varium Scytonema varium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QT4 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qt4 OCA], [https://pdbe.org/2qt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qt4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qt4 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qt4 OCA], [https://pdbe.org/2qt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qt4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qt4 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SVN_SCYVA SVN_SCYVA] Has strong anti-HIV activity against T-tropic strains of HIV-1 and weaker activity against M-tropic strains of HIV-1. Inhibits HIV-1 fusion and infection of CD4 LTR beta-gal cells in vitro. Inhibits fusion of HIV infected CEM-SS cells with uninfected CEM-SS cells, and fusion of HIV-1 Env expressing HL2/3 cells with CD4 LTR beta-gal cells. Binds to HIV gp120, HIV gp160 and to a lesser extent HIV gp41. Binding to HIV gp120 is glycosylation dependent. Binds with high specificity to the tetrasaccharide Man-alpha-1,2-Man-alpha-1,6-Man-alpha-1,6-Man and also binds the higher-order oligosaccharides oligomannose 8 and oligomannose 9. Does not bind to monosaccharides, complex or hybrid N-linked oligosaccharides or chitin.<ref>PMID:12614152</ref> <ref>PMID:16647158</ref> <ref>PMID:17269926</ref> <ref>PMID:17434526</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Scytonema varium]] | [[Category: Scytonema varium]] | ||
[[Category: Botos | [[Category: Botos I]] | ||
[[Category: Dauter | [[Category: Dauter Z]] | ||
[[Category: Moulaei | [[Category: Moulaei T]] | ||
[[Category: Wlodawer | [[Category: Wlodawer A]] | ||
[[Category: Ziolkowska | [[Category: Ziolkowska NE]] | ||
Revision as of 06:50, 7 April 2023
Atomic-resolution crystal structure of the natural form of Scytovirin
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