4wba: Difference between revisions
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<StructureSection load='4wba' size='340' side='right'caption='[[4wba]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4wba' size='340' side='right'caption='[[4wba]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4wba]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4wba]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_rotavirus_A/SA11 Simian rotavirus A/SA11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WBA FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wba OCA], [https://pdbe.org/4wba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wba RCSB], [https://www.ebi.ac.uk/pdbsum/4wba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wba ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/O92323_9VIRU O92323_9VIRU] Plays an essential role in the virus replication cycle by acting as a viroporin. Creates a pore in the host reticulum endoplasmic and as a consequence releases Ca(2+) in the cytoplasm of infected cell. In turn, high levels of cytoplasmic calcium trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication and immature particle assembly.[HAMAP-Rule:MF_04091] The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.[HAMAP-Rule:MF_04091] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Simian | [[Category: Simian rotavirus A/SA11]] | ||
[[Category: Estes | [[Category: Estes MK]] | ||
[[Category: Horton | [[Category: Horton LB]] | ||
[[Category: Hyser | [[Category: Hyser JM]] | ||
[[Category: Prasad | [[Category: Prasad BVV]] | ||
[[Category: Sankaran | [[Category: Sankaran B]] | ||
[[Category: Sastri | [[Category: Sastri NP]] | ||
[[Category: Tanner | [[Category: Tanner MR]] | ||
[[Category: Viskovska | [[Category: Viskovska M]] | ||
