4wil: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[4wil]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIL OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WIL FirstGlance].

<table><tr><td colspan='2'>[[4wil]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIL OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4WIL FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">Pcbd2, Dcoh2, Dcohm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4wil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wil OCA], [https://pdbe.org/4wil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wil RCSB], [https://www.ebi.ac.uk/pdbsum/4wil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wil ProSAT]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/4a-hydroxytetrahydrobiopterin_dehydratase 4a-hydroxytetrahydrobiopterin dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.96 4.2.1.96] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wil OCA], [~~http~~://pdbe.org/4wil PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wil RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wil PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wil ProSAT]</td></tr>

</table>

== Function ==

[~~[http~~://www.uniprot.org/uniprot/PHS2_MOUSE PHS2_MOUSE]] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

[https://www.uniprot.org/uniprot/PHS2_MOUSE PHS2_MOUSE] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

== Publication Abstract from PubMed ==

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__TOC__

</StructureSection>

~~[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]~~

[[Category: Large Structures]]

[[Category: ~~Lk3 transgenic mice~~]]

[[Category: Mus musculus]]

[[Category: Rose~~, R B~~]]

[[Category: Rose RB]]

[[Category: Wang, D]]

[[Category: Wang D]]

~~[[Category: Bifunctional]]~~

~~[[Category: Coactivator]]~~

~~[[Category: Kinetic stability]]~~

~~[[Category: Lyase]]~~

~~[[Category: Tetrahydrobiopterin recycling~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='4wil' size='340' side='right'caption='[[4wil]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4wil]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WIL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4wil]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WIL FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pcbd2, Dcoh2, Dcohm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wil OCA], [https://pdbe.org/4wil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wil RCSB], [https://www.ebi.ac.uk/pdbsum/4wil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wil ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4a-hydroxytetrahydrobiopterin_dehydratase 4a-hydroxytetrahydrobiopterin dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.96 4.2.1.96] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wil OCA], [http://pdbe.org/4wil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wil RCSB], [http://www.ebi.ac.uk/pdbsum/4wil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wil ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PHS2_MOUSE PHS2_MOUSE]] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).  Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
+[https://www.uniprot.org/uniprot/PHS2_MOUSE PHS2_MOUSE] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).  Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Rose, R B]]
+[[Category: Rose RB]]
-[[Category: Wang, D]]
+[[Category: Wang D]]
-[[Category: Bifunctional]]
-[[Category: Coactivator]]
-[[Category: Kinetic stability]]
-[[Category: Lyase]]
-[[Category: Tetrahydrobiopterin recycling]]