4wne: Difference between revisions

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<StructureSection load='4wne' size='340' side='right'caption='[[4wne]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4wne' size='340' side='right'caption='[[4wne]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WNE FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sf4|3sf4]], [[4wnd|4wnd]], [[4wnf|4wnf]], [[4wng|4wng]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wne OCA], [https://pdbe.org/4wne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wne RCSB], [https://www.ebi.ac.uk/pdbsum/4wne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wne ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPSM2, LGN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wne OCA], [http://pdbe.org/4wne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wne RCSB], [http://www.ebi.ac.uk/pdbsum/4wne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wne ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/GPSM2_HUMAN GPSM2_HUMAN]] Autosomal recessive nonsyndromic sensorineural deafness type DFNB;Chudley-McCullough syndrome. Chudley-McCullough syndrome (CMCS) [MIM:[http://omim.org/entry/604213 604213]]: An autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia. Some patients have hydrocephalus. Psychomotor development is normal. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:20602914</ref> <ref>PMID:22578326</ref> [[http://www.uniprot.org/uniprot/FRPD4_HUMAN FRPD4_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
[https://www.uniprot.org/uniprot/GPSM2_HUMAN GPSM2_HUMAN] Autosomal recessive nonsyndromic sensorineural deafness type DFNB;Chudley-McCullough syndrome. Chudley-McCullough syndrome (CMCS) [MIM:[https://omim.org/entry/604213 604213]: An autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia. Some patients have hydrocephalus. Psychomotor development is normal. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:20602914</ref> <ref>PMID:22578326</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GPSM2_HUMAN GPSM2_HUMAN]] Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.<ref>PMID:15632202</ref> [[http://www.uniprot.org/uniprot/FRPD4_HUMAN FRPD4_HUMAN]] Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.<ref>PMID:19118189</ref> 
[https://www.uniprot.org/uniprot/GPSM2_HUMAN GPSM2_HUMAN] Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.<ref>PMID:15632202</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sumimoto, H]]
[[Category: Sumimoto H]]
[[Category: Takayanagi, H]]
[[Category: Takayanagi H]]
[[Category: Yuzawa, S]]
[[Category: Yuzawa S]]
[[Category: Cell polarity]]
[[Category: Cytoplasm and cell cortex]]
[[Category: Signaling protein-protein binding complex]]
[[Category: Tetratricopeptide repeat]]
[[Category: Tpr]]
Retrieved from "https://proteopedia.org/4wne"