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==Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 5-nitrouracil, Form III==
==Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 5-nitrouracil, Form III==
<StructureSection load='4ws5' size='340' side='right' caption='[[4ws5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='4ws5' size='340' side='right'caption='[[4ws5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ws5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WS5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ws5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WS5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5NU:5-NITROURACIL'>5NU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NU:5-NITROURACIL'>5NU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wru|4wru]], [[4wrv|4wrv]], [[4wrw|4wrw]], [[4wrx|4wrx]], [[4wry|4wry]], [[4wrz|4wrz]], [[4ws0|4ws0]], [[4ws1|4ws1]], [[4ws2|4ws2]], [[4ws3|4ws3]], [[4ws4|4ws4]], [[4ws6|4ws6]], [[4ws7|4ws7]], [[4ws8|4ws8]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ws5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ws5 OCA], [https://pdbe.org/4ws5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ws5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ws5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ws5 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ung, Rv2976c, MTCY349.11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ws5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ws5 OCA], [http://pdbe.org/4ws5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ws5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ws5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ws5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).  
[https://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ws5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ws5" style="background-color:#fffaf0;"></div>
==See Also==
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Uracil-DNA glycosylase]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Arif, S M]]
[[Category: Arif SM]]
[[Category: Geethanandan, K]]
[[Category: Geethanandan K]]
[[Category: Mishra, P]]
[[Category: Mishra P]]
[[Category: Surolia, A]]
[[Category: Surolia A]]
[[Category: Varshney, U]]
[[Category: Varshney U]]
[[Category: Vijayan, M]]
[[Category: Vijayan M]]
[[Category: Conformational selection]]
[[Category: Dna-repair]]
[[Category: Excision repair]]
[[Category: Hydrolase]]
[[Category: Ligand-binding]]
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