4wsr: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 3: Line 3:
<StructureSection load='4wsr' size='340' side='right'caption='[[4wsr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4wsr' size='340' side='right'caption='[[4wsr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wsr]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/chicken/ny/14677-13/1998(h6n2)) Influenza a virus (a/chicken/ny/14677-13/1998(h6n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wsr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/chicken/New_York/14677-13/1998(H6N2)) Influenza A virus (A/chicken/New York/14677-13/1998(H6N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WSR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsr OCA], [https://pdbe.org/4wsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wsr RCSB], [https://www.ebi.ac.uk/pdbsum/4wsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsr ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wss|4wss]], [[4wst|4wst]], [[4wsu|4wsu]], [[4wsv|4wsv]], [[4wsw|4wsw]], [[4wsx|4wsx]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=402503 Influenza A virus (A/chicken/NY/14677-13/1998(H6N2))])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsr OCA], [http://pdbe.org/4wsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wsr RCSB], [http://www.ebi.ac.uk/pdbsum/4wsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q0A3A5_9INFA Q0A3A5_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]  
[https://www.uniprot.org/uniprot/Q0A3A5_9INFA Q0A3A5_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 20:


==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 29: Line 26:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Carney, P J]]
[[Category: Carney PJ]]
[[Category: Chang, J C]]
[[Category: Chang JC]]
[[Category: Stevens, J]]
[[Category: Stevens J]]
[[Category: Villanueva, J M]]
[[Category: Villanueva JM]]
[[Category: Yang, H]]
[[Category: Yang H]]
[[Category: H6]]
[[Category: Hemagglutinin]]
[[Category: Influenza virus]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/4wsr"