Sandbox Reserved 1785: Difference between revisions

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===Fab Region===

The Fab region of the antibody is where antigen recognition occurs upon binding. On each arm is one heavy and one light chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the constant and variable domains ~~(blue link)~~ within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the <scene name='95/952713/Variable_region/1'>variable region</scene> (cite).

The Fab region of the antibody is where antigen recognition occurs upon binding. On each arm is one heavy and one light chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the [https://en.wikipedia.org/wiki/Antibody constant and variable domains] within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the <scene name='95/952713/Variable_region/1'>variable region</scene> (cite).

The IgM-BCR contains areas referred to as [https://en.wikipedia.org/wiki/Complementarity-determining_region complementary-determining regions](CDRs), which are where the antigen makes contact with the antibody on the Fab domain. Figure 2 depicts this as a surface representation on one of the IgM arms given that the specific residues within the antigen-binding motif are unknown.

Sandbox Reserved 1785: Difference between revisions

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@@ Line 39: / Line 39: @@
 ===Fab Region===
-The Fab region of the antibody is where antigen recognition occurs upon binding. On each arm is one heavy and one light chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the constant and variable domains (blue link) within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the  <scene name='95/952713/Variable_region/1'>variable region</scene> (cite).
+The Fab region of the antibody is where antigen recognition occurs upon binding. On each arm is one heavy and one light chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the [https://en.wikipedia.org/wiki/Antibody constant and variable domains] within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the  <scene name='95/952713/Variable_region/1'>variable region</scene> (cite).
 The IgM-BCR contains areas referred to as [https://en.wikipedia.org/wiki/Complementarity-determining_region complementary-determining regions](CDRs), which are where the antigen makes contact with the antibody on the Fab domain. Figure 2 depicts this as a surface representation on one of the IgM arms given that the specific residues within the antigen-binding motif are unknown.