Sandbox Reserved 1792: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Grace Lane (talk | contribs) No edit summary |
Grace Lane (talk | contribs) No edit summary |
||
| Line 23: | Line 23: | ||
== Active vs Inactive State== | == Active vs Inactive State== | ||
[[Image: | [[Image:Inactive v active proteopedia.png|300 px|right|thumb| An overview of the Inactive (red) vs Active (green) state of TSHR. PDB: 7WX5]] | ||
When TSHR is not bound to TSH, it is in the <scene name='95/952720/Inactivetshr/7'>inactive state</scene>. This is also considered the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashing between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene>. During this transition, the Extracellular domains rotate 55° along an axis. This rotation is caused by conformational changes within the <scene name='95/952720/Hinge_region_spin/1'>Hinge Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/2'>Y279 residue</scene>. This residue moves 6 angstroms relative to I486, which is a residue located in the Transmembrane Region <ref name="Faust"/> | When TSHR is not bound to TSH, it is in the <scene name='95/952720/Inactivetshr/7'>inactive state</scene>. This is also considered the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashing between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene>. During this transition, the Extracellular domains rotate 55° along an axis. This rotation is caused by conformational changes within the <scene name='95/952720/Hinge_region_spin/1'>Hinge Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/2'>Y279 residue</scene>. This residue moves 6 angstroms relative to I486, which is a residue located in the Transmembrane Region <ref name="Faust"/> | ||
== Specific Residues == | == Specific Residues == | ||
