Sandbox Reserved 1788: Difference between revisions
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== SHOC2 and MRAS == | == SHOC2 and MRAS == | ||
MRAS is initially bound to GDP causing it to be in its inactive state. This form cannot bind to the SHOC2-PP1C complex due to steric clashing (Figure 2). Once GDP is exchanged for GTP to activate the protein, <scene name='95/952716/ | MRAS is initially bound to GDP causing it to be in its inactive state. This form cannot bind to the SHOC2-PP1C complex due to steric clashing (Figure 2). Once GDP is exchanged for GTP to activate the protein, <scene name='95/952716/Scho2-mras-interactions/1'>conformational changes</scene> occur within the switch I and switch II regions to allow <scene name='95/952716/MRAS to interact with SHOC2/2'>SHOC2-MRAS(full-image)</scene>. These <scene name='95/952716/Scho2-mras-interactions/1'>interactions</scene> include hydrogen bonds and pi stacking. The primary hydrogen bonds are R288-Q71 and R177-E47. Pi staking occurs at R104-R83. | ||
