Sandbox Reserved 1794: Difference between revisions
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=== Binding Sites === | === Binding Sites === | ||
==== Sodium ==== | ==== Sodium ==== | ||
NTCP, among others in the SLC10 family, have <scene name='95/952721/Sodium_binding/5'>two sodium binding sites</scene>. Many polar and negatively charged residues are characteristic of these active sites. The high level of conservation among sodium binding placement and interacting residues suggests sodium binding is coupled to bile salt transport. Additional mutations in the X-motif near sodium binding sites have shown that bile salt transport function is lost. This suggests sodium binding impacts bile salt binding. | NTCP, among others in the SLC10 family, have <scene name='95/952721/Sodium_binding/5'>two sodium binding sites</scene>. Many polar and negatively charged residues are characteristic of these active sites. The high level of conservation among sodium binding placement and interacting residues suggests sodium binding is coupled to bile salt transport. Additional mutations in the X-motif near sodium binding sites have shown that bile salt transport function is lost. This suggests sodium binding impacts bile salt binding. | ||
