Sandbox Reserved 1766: Difference between revisions

<scene name='95/952694/Overall_image/2'>SHOC2-MRAS-PP1C</scene>, also known as the SMP complex, is a 3-subunit complex essential for cell proliferation and the survival of many cancers and RASopathies. When the subunits come together, it plays a key role in the activation of the Ras-Raf pathway and signaling cascade, which drives cell proliferation.<ref name="Hauseman">PMID:35830882</ref> Each subunit of the complex has an individual structure which correlates with its function. SHOC2 has a crescent shape in order to enhance substrate interactions and interactions between the subunits, while PP1C holds the catalytic active site and, the C-terminus of MRAS localizes the complex to the cell membrane. Mutations in one or multiple of these subunits leads to over-activation of the signaling pathway, leading to cancer and developmental disorders called RASopathies. The signaling cascade is kept from over-activating by being held in an auto-inhibited conformation. The SMP complex is responsible for removing this auto-inhibited conformation, allowing for Raf to bind to Ras. Mutations in the subunits can lead to more frequent complex formation, ultimately leading to more, often uncontrolled, cell proliferation.<ref name="Kwon">PMID: 35831509</ref> SHOC2-PP1C-MRAS is being studied as a possible treatment target for many types of cancers.