Sandbox Reserved 1784: Difference between revisions
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== Significance == | == Significance == | ||
NTCP is a key player in the absorption and digestion of fats and fat-soluble vitamins in the body, as well as the synthesis of bile within the liver. The uptake of bile salts, transcriptional and post-transcriptional, are signaling molecules for the liver and intestine. Bile salt, the transporting molecule of NTCP, aids in the absorption of lipophilic nutrients and vitamins in the small intestine. Additionally, bile salt plays a role in the endocrine system, excretion of toxins, and cholesterol maintenance. ADD GOUTAM REFERENCE HERE. Thus, the significance of NTCP lies with the importance of bile salts; NTCP is necessary in maintaining bile salt levels and thus necessary in maintaining the aforementioned biological processes. | |||
=== Bile Salt Uptake === | === Bile Salt Uptake === | ||
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[[Image:Bile Salt structure.png|300 px|left|thumb|'''Figure 2.''' Bile Salt Structure.]] | [[Image:Bile Salt structure.png|300 px|left|thumb|'''Figure 2.''' Bile Salt Structure.]] | ||
Cirrhosis, commonly known as the last stage of liver disease, is due to a deficiency in the bile acid supply in the liver. Bile acid pools, as defined by Vlahcevic, are the negatively-charged precursors to bile and often are conjugated to positively-charged bile salts. This is attributed either a decrease in the production of bile salts or a large increase in the excretion of this molecule out of the cell. https://www.gastrojournal.org/article/S0016-5085(71)80053-7/pdf This disease is transferred through bodily fluids between organisms. Liver Disease causes symptoms such as jaundice, abdominal pain and swelling, and swelling of the legs and feet. Liver disease can lead to liver cancer and other life-threatening diseases, making bile salt uptake essential to liver function. | |||
=== HBV/HDV === | === HBV/HDV === | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
