Sandbox Reserved 1777: Difference between revisions
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=Activation of RAF= | =Activation of RAF= | ||
[[Image:Screen Shot 2023-04-10 at 4.34.56 PM.jpeg| | [[Image:Screen Shot 2023-04-10 at 4.34.56 PM.jpeg|600px|thumb|<font size="2"><div style="text-align: center;">'''Figure 3'''. Schematic representation of RAF activation. </div></font>]] | ||
Once the SMP complex comes together, it plays a key role in regulating the activation of the RAF and MAPK pathway. To do so, PP1C, enhanced through the interactions with SHOC2 and MRAS, phosphorylates serine 259 on RAF kinases. Doing so regulates cell growth, survival, proliferation, and differentiation <Ref name='Lavoie'>Lavoie, H., Therrien, M. Structural keys unlock RAS–MAPK cellular signalling pathway. Nature 609, 248-249 (2022). doi: 10.1038/d41586-022-02189-7. [https://doi.org/10.1038/d41586-022-02189-7. DOI:10.1038/d41586-022-02189-7]. </Ref>. | Once the SMP complex comes together, it plays a key role in regulating the activation of the RAF and MAPK pathway. To do so, PP1C, enhanced through the interactions with SHOC2 and MRAS, phosphorylates serine 259 on RAF kinases. Doing so regulates cell growth, survival, proliferation, and differentiation <Ref name='Lavoie'>Lavoie, H., Therrien, M. Structural keys unlock RAS–MAPK cellular signalling pathway. Nature 609, 248-249 (2022). doi: 10.1038/d41586-022-02189-7. [https://doi.org/10.1038/d41586-022-02189-7. DOI:10.1038/d41586-022-02189-7]. </Ref>. | ||
