Sandbox Reserved 1766: Difference between revisions
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The signaling cascade is kept from over-activating by being held in an auto-inhibited conformation. The SMP complex is responsible for removing this auto-inhibited conformation, allowing for Raf to bind to Ras. Mutations in any member of the SMP complex can lead to more frequent complex formation, ultimately leading to more, often uncontrolled, cell proliferation.<ref name="Kwon">PMID: 35831509</ref> SHOC2-PP1C-MRAS is being studied as a possible treatment target for many types of cancers. | The signaling cascade is kept from over-activating by being held in an auto-inhibited conformation. The SMP complex is responsible for removing this auto-inhibited conformation, allowing for Raf to bind to Ras. Mutations in any member of the SMP complex can lead to more frequent complex formation, ultimately leading to more, often uncontrolled, cell proliferation.<ref name="Kwon">PMID: 35831509</ref> SHOC2-PP1C-MRAS is being studied as a possible treatment target for many types of cancers. | ||
In all images and animations, SHOC2 will be shown as cyan blue, MRAS as lime, and PP1C as violet. Other important components involved in the function of the SMP complex include the 14-3-3 dimer and Raf, which will be shown in salmon and slate-blue, respectively. | In all images and animations, {{Font color|cyan|SHOC2}} will be shown as cyan blue, {{Font color|lime|MRAS}} as lime, and {{Font color|violet|PP1C}} as violet. Other important components involved in the function of the SMP complex include the {{Font color|salmon|14-3-3}} dimer and {{Font color|slate-blue|Raf}}, which will be shown in salmon and slate-blue, respectively. | ||
== Significance == | == Significance == | ||
