7yf4: Difference between revisions
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==Crystal structure of METTL9 in complex with SLC39A5 mutant peptide and SAH== | |||
<StructureSection load='7yf4' size='340' side='right'caption='[[7yf4]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yf4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YF4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yf4 OCA], [https://pdbe.org/7yf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yf4 RCSB], [https://www.ebi.ac.uk/pdbsum/7yf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yf4 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/METL9_HUMAN METL9_HUMAN] Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) (PubMed:33563959). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959).<ref>PMID:33563959</ref> <ref>PMID:34562450</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Wang X]] | |||
[[Category: Xie H]] | |||
[[Category: Xu C]] | |||
Revision as of 20:28, 12 April 2023
Crystal structure of METTL9 in complex with SLC39A5 mutant peptide and SAH
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